【ACRO 線上擁有超過40種以上

通過SPR / BLI / ELISA驗證的具有多重物種和標籤的Fc受體】

治療性抗體的功效不僅取決於Fab片段及其與目標抗原的結合活性，

還取決於Fc片段及其與關鍵Fc受體的相互作用。

40+ Fc receptors with multiple species and tags verified by SPR/BLI/ELISA

The efficacy of a therapeutic antibody not only depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors. The binding affinity of the Fc fragment towards FcRn (FCGRT&B2M) would predict the antibody’s half-life, while that between the Fc fragment and FcγRIIIa (CD16a) would influence the antibody’s ability to elicit ADCC (antibody dependent cell mediated cytotoxicity). Therefore, candidates must be tested against a panel of receptors during antibody engineering.

ACROBiosystems offers 47 Fc receptors with different molecules, species, tags and biotin conjunction to help expedite your mAb development.

Features

※ High purity，bioactivity and batch-to-batch consistency

※ HPLC/SPR/BLI verified and protocol offered for free

※ Biotinylated ones are available

Find out more

DATA

※ High purity

Fig. 1 The purity of Human Fc gamma RIIA / CD32a (R167) Protein (Cat. No. CDA-H5221) is greater than 95% as determined in a HPLC analysis.

Protocol

※ Bioactivity validated by SPR

Fig. 2 Human CD64, His Tag (SPR & BLI verified) (Cat. No. FCA-H52H1) captured on CM5 chip via anti-His antibody can bind Herceptin with an affinity constant of 4.92 nM as determined in a SPR assay (Biacore 8K)

Protocol

※High Batch-to-batch Consistency

Fig. 3 Batch consistency of Human Fc gamma RIIB / CD32b (Cat. No. CDB-H5228). The consistency of different batches is more than 90%.

Protocol

※ Biotinylated CD16a and more

ACRO | 超過40種具有多重物種和標籤的Fc受體

ACRO | 超過40種具有多重物種和標籤的Fc受體

【ACRO 線上擁有超過40種以上

通過SPR / BLI / ELISA驗證的具有多重物種和標籤的Fc受體】

治療性抗體的功效不僅取決於Fab片段及其與目標抗原的結合活性，

還取決於Fc片段及其與關鍵Fc受體的相互作用。

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